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Article

Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes

8 Feb 2019

Abstract excerpt

The connection between Zika virus (ZIKV) and neurodevelopmental defects is widely recognized, although the mechanisms underlying the infectivity and pathology in primary human glial cells are poorly understood. Here we show that three isolated strains of ZIKV, an African strain MR766 (Uganda) and two closely related Asian strains R103451 (Honduras) and PRVABC59 (Puerto Rico) productively infect primary human...

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PMID: 30735502
DOI: 10.1371/journal.pone.0208543

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