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Article

Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases

17 Oct 2023

Abstract excerpt

The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks. However, unsuccessful repair can result in podocytes crossing the G1/S checkpoint and undergoing abortive cytokinesis. In this study, we identified Pfn1 as indispensable in maintaining glomerular integrity...

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PMID: 37847555
DOI: 10.1172/jci171237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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