Article

A FRET Based Assay for the Identification of PCNA Inhibitors

2023-07-06

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) is the key regulator of human DNA metabolism. One important interaction partner is p15, involved in DNA replication and repair. Targeting the PCNA-p15 interaction is a promising therapeutic strategy against cancer. Here, a Förster resonance energy transfer (FRET)-based assay for the analysis of PCNA-p15 interaction was developed. Next to the application as screening tool f...

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Literature Corpus work: 4b73c11f-99f3-55b5-8eeb-a0b76039ace2
DOI: 10.20944/preprints202307.0433.v1

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