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Article

Crystallographic study of G178S mutant of human proliferating cell nuclear antigen.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Sept 2008

Hishiki Asami, Shimizu Toshiyuki, Serizawa Aya, Ohmori Haruo, Sato Mamoru, Hashimoto Hiroshi

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) is an evolutionarily conserved protein that forms a ring-shaped homotrimer that functions as a sliding clamp for DNA replication. The rev6-1 mutation of Saccharomyces cerevisiae, which inactivates both translesion DNA synthesis and damage-avoidance pathways while having little effect on normal cell growth, has a G178S substitution in the PCNA protein. Human PCNA protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18765913
DOI: 10.1107/S174430910802277X
PMCID: PMC2531271

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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