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Article

A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design.

Oncogene - 11 May 2006

Warbrick E

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform to mediate protein interactions with the DNA strand. Many proteins interact with PCNA through a small conserved motif with consensus QxxLxxFF. This work uses Schizosaccharomyces pombe and human cells to analyse the function of PCNA-binding peptides. Interacting peptides were identified using...

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Source

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Identifiers

PMID: 16407840
DOI: 10.1038/sj.onc.1209320
PMCID: PMC2699888

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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