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Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi

2024-03-26

Abstract excerpt

Since the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) in Malawi in 2011, there has been persistent carriage of vaccine serotype (VT) Streptococcus pneumoniae , despite high vaccine coverage. To determine if there has been a genetic change within the VT capsule polysaccharide (cps) loci since the vaccine’s introduction, we compared 1,022 whole-genome-sequenced VT isolates from 1998 to 2019...

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Literature Corpus work
4b56e301-931b-56bb-b992-faa6411d95ec
DOI
10.1101/2024.03.25.586540
Open publication

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Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, MalawiDOI 10.1101/2024.03.25.586540
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