Article

Early signals of vaccine driven perturbation seen in pneumococcal carriage population genomic data

2018-11-01

Abstract excerpt

Pneumococcal conjugate vaccines (PCV) have reduced pneumococcal diseases globally. Despite this, much remains to be learned about their effect on pathogen population structure. Here we undertook whole genome sequencing of 660 pneumococcal strains from asymptomatic carriers to investigate population restructuring in pneumococcal strains sampled before and after PCV13 introduction in a previously vaccine-naïve setti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2a8da80-70dd-53b2-82fc-c7df5c459aa9
DOI: 10.1101/459693

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early signals of vaccine driven perturbation seen in pneumococcal carriage population genomic dataDOI 10.1101/459693Read

Population genetic structure, antibiotic resistance, capsule switching and evolution of invasive pneumococci before conjugate vaccination in MalawiSemantic proximity Read

The metabolic, virulence and antimicrobial resistance profiles of colonizing <i>Streptococcus pneumoniae</i> shift after pneumococcal vaccine introduction in urban MalawiSemantic proximity Read

The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban MalawiSemantic proximity Read

Genetic characterisation of Malawian pneumococci prior to the roll-out of the PCV13 vaccine using a high-throughput whole genome sequencing approach.Semantic proximity Read

Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, MalawiSemantic proximity Read

Population genomics of pneumococcal carriage in Massachusetts children following introduction of PCV-13.Semantic proximity Read

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing studySemantic proximity Read

Population genomics of post-vaccine changes in pneumococcal epidemiology.Semantic proximity Read

Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi.Semantic proximity Read

The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genomeSemantic proximity Read

Pneumococcal vaccine impacts on the population genomics of non-typeable Haemophilus influenzae.Semantic proximity Read

Prediction of post-PCV13 pneumococcal evolution using invasive disease data enhanced by inverse-invasiveness weightingSemantic proximity Read