Article
Clonal Expansion of a Streptococcus pneumoniae Serotype 3 Capsule Variant Sequence Type 700 With Enhanced Vaccine Escape Potential After 13-Valent Pneumococcal Conjugate Vaccine Introduction.
The Journal of infectious diseases - 25 Jul 2024
Kalizang'oma Akuzike, Swarthout Todd D, Mwalukomo Thandie S, Kamng'ona Arox, Brown Comfort, Msefula Jacquline, Demetriou Hayley, Chan Jia Mun, Roalfe Lucy, Obolski Uri, Lourenço Jose, Goldblatt David, Chaguza Chrispin, French Neil, Heyderman Robert S
Abstract excerpt
BACKGROUND: Streptococcus pneumoniae serotype 3 remains a problem globally. Malawi introduced 13-valent pneumococcal conjugate vaccine (PCV13) in 2011, but there has been no direct protection against serotype 3 carriage. We explored whether vaccine escape by serotype 3 is due to clonal expansion of a lineage with a competitive advantage. METHODS: The distribution of serotype 3 Global Pneumococcal Sequence...
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