Article
Murine gamma-herpesvirus immortalization of fetal liver-derived B cells requires both the viral cyclin D homolog and latency-associated nuclear antigen.
PLoS pathogens - 1 Sept 2011
Liang Xiaozhen, Paden Clinton R, Morales Francine M, Powers Ryan P, Jacob Joshy, Speck Samuel H
Abstract excerpt
Human gammaherpesviruses are associated with the development of lymphoproliferative diseases and B cell lymphomas, particularly in immunosuppressed hosts. Understanding the molecular mechanisms by which human gammaherpesviruses cause disease is hampered by the lack of convenient small animal models to study them. However, infection of laboratory strains of mice with the rodent virus murine gammaherpesvirus 68...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.