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Colonization resistance against Clostridioides difficile is a graded, microbiota-intrinsic property of healthy human gut communities

2026-08-27

Abstract excerpt

Fecal microbiota transplantation cures approximately 90% of recurrent Clostridioides difficile infection, yet it remains unknown whether all healthy donor microbiota confer equivalent protection. We colonized germ-free C57BL/6 mice with stool microbiota from 30 healthy human donors and challenged them with C. difficile in the absence of antibiotic pretreatment. Donor microbiota conferred a spectrum of colonization...

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Literature Corpus work
7a58a3b3-9d1a-5d45-b87c-c45cb224c1e6
DOI
10.64898/2026.08.26.747331
Open publication

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Colonization resistance against Clostridioides difficile is a graded, microbiota-intrinsic property of healthy human gut communitiesDOI 10.64898/2026.08.26.747331
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