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Host origin of microbiota drives functional recovery and Clostridioides difficile clearance in mice

2 Jun 2025

Abstract excerpt

ABSTRACT Colonization resistance provided by the gut microbiota is essential for resisting both initial Clostridioides difficile infection (CDI) and potential recurrent infection (rCDI). Although fecal microbiota transplantation (FMT) has been successful in treating rCDI by restoring microbial composition and function, mechanisms underlying the efficacy of standardized stool-derived products remain poorly...

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PMID: 40454811
DOI: 10.1128/mbio.01108-25

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