Prevalence of somatic SF3B1R625H mutation in lactotroph tumours from a multi-centric cohort: a digital PCR-based study.

doi:10.1093/ejendo/lvag098

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Article

Prevalence of somatic SF3B1R625H mutation in lactotroph tumours from a multi-centric cohort: a digital PCR-based study.

European journal of endocrinology - 1 Jun 2026

Rai Ashutosh, Barry Sayka, Mangili Federica, Barbieri Anna Maria, Scheich Bálint, Iacovazzo Donato, Chatterjee Debojyoti, Rice Tom, Begalli Federica, Roncaroli Federico, Magid Kesson, Suleyman Oniz, Szücs Nikolette, Tőke Judit, Herrera-Martínez Aura D, Soto-Moreno Alfonso, López-Fernández Judith, G-Garcia Miguel E, Luque Raul M, Guaraldi Federica, Mazzatenta Diego, Gentilini Francesca, Asioli Sofia, Mangone Alessandra, Locatelli Marco, Lania Andrea G, Tóth Miklós, Dutta Pinaki, Mantovani Giovanna, Peverelli Erika, Korbonits Márta

Abstract excerpt

OBJECTIVE: An SF3B1 (Somatic splicing factor 3B subunit 1) mutation has been associated with prolactin-secreting pituitary neuroendocrine tumours (PitNET) with increased proliferation, invasion, dopamine agonist resistance and reduced progression-free survival. DESIGN: We screened a multi-centric cohort of 127 patients with prolactin-secreting PitNET for the SF3B1R625H mutation using digital PCR. METHODS: A...

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PMID: 42294999
DOI: 10.1093/ejendo/lvag098

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SF3B1

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