Article

Impaired dendritic spine development in a zebrafish model of Fragile X

2022-02-16

Abstract excerpt

Dendritic spines are the principal site of excitatory synapse formation in the human brain. Impaired formation of spines during development has been observed in several autism spectrum disorders (ASDs), including Fragile X syndrome. Fragile X is caused by transcriptional silencing of the Fmr1 gene encoding the RNA-binding protein FMRP (Fragile X mental retardation protein). While spine development has been well c...

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Literature Corpus work: 4b3af510-5cb8-5c5a-9509-517eb82832e9
DOI: 10.1101/2022.02.15.480580

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