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Article

Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice.

PloS one - 1 Jan 2012

Cruz-Martín Alberto, Crespo Michelle, Portera-Cailliau Carlos

Abstract excerpt

Fragile X syndrome (FXS), the most common inherited from of autism and mental impairment, is caused by transcriptional silencing of the Fmr1 gene, resulting in the loss of the RNA-binding protein FMRP. Dendritic spines of cortical pyramidal neurons in affected individuals are abnormally immature...

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Identifiers

PMID: 22384253
DOI: 10.1371/journal.pone.0032446
PMCID: PMC3288094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22384253-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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