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Article

A monkey model of acetaminophen-induced hepatotoxicity; phenotypic similarity to human.

The Journal of toxicological sciences - 1 Jan 2017

Tamai Satoshi, Iguchi Takuma, Niino Noriyo, Mikamoto Kei, Sakurai Ken, Sayama Ayako, Shimoda Hitomi, Takasaki Wataru, Mori Kazuhiko

Abstract excerpt

Species-specific differences in the hepatotoxicity of acetaminophen (APAP) have been shown. To establish a monkey model of APAP-induced hepatotoxicity, which has not been previously reported, APAP at doses up to 2,000 mg/kg was administered orally to fasting male and female cynomolgus monkeys (n = 3-5/group) pretreated intravenously with or without 300 mg/kg of the glutathione biosynthesis inhibitor,...

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PMID: 28070111
DOI: 10.2131/jts.42.73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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