Back to search

Article

Variants in <i>Lrrk2</i> and <i>Snca</i> deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice

2024-09-28

Abstract excerpt

Variants of the leucine-rich repeat kinase-2 ( LRRK2 ) and α-synuclein ( SNCA ) genes are associated with Parkinson’s disease risk. We previously demonstrated that two Lrrk2 knock-in variants as well as Snca expression alter survival rates from combined pneumonitis and encephalitis following intranasal inoculation of newborn mice with a double-stranded RNA virus: respiratory-enteric-orphan virus, serotype-3 st...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4b1dca88-99fe-57a2-854e-c562ae89c4a2
DOI
10.1101/2024.09.28.615578
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Variants in <i>Lrrk2</i> and <i>Snca</i> deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn miceDOI 10.1101/2024.09.28.615578
Elevated brain α-synuclein, phosphorylated-tau, and oxidative stress in mice that survived influenza A pneumonitisSemantic proximity
Gut bacterial Infection drives Parkinsonian pathology in LRRK2 G2019S Knock-in MiceSemantic proximity
Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in AgingSemantic proximity
A role for dual viral hits in causation of subacute sclerosing panencephalitis.Semantic proximity
Development and characterization of an animal model of Japanese encephalitis virus infection in adolescent C57BL/6 mouse.Semantic proximity
Sublethal Enteroviral Infection Exacerbates Disease Progression in an ALS Mouse ModelSemantic proximity
Modelling tick-borne encephalitis in infant rat mimics important aspects of human diseaseSemantic proximity
Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.Semantic proximity
Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infectionSemantic proximity
Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control.Semantic proximity
Neurotropism of enterovirus D68 isolates is independent of sialic acid and is not a recently acquired phenotypeSemantic proximity
Impaired development of the cerebellum in transgenic mice expressing the immediate-early protein IE180 of pseudorabies virus.Semantic proximity
Select a neighboring publication to make it the new centre.