Article

Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitment

2019-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Duchenne muscular dystrophy (DMD) causes severe disability of children and death of young men, with an incidence of approximately 1/5,000 male births. Symptoms appear in early childhood, with a diagnosis made around 4 years old, a time where the amount of muscle damage is already significant, preventing early therapeutic interventions that could be more efficient at halting disease progression....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 84aaf683-78ff-5d55-803d-48ef02da48ca
DOI: 10.1101/720920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Myogenesis modelled by human pluripotent stem cells uncovers Duchenne muscular dystrophy phenotypes prior to skeletal muscle commitmentDOI 10.1101/720920Read

Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onsetSemantic proximity Read

Generation of Skeletal Muscle Organoids from Human Pluripotent Stem CellsSemantic proximity Read

Human induced pluripotent stem cell models for the study and treatment of Duchenne and Becker muscular dystrophiesSemantic proximity Read

iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modelingSemantic proximity Read

Dystrophin deficiency impairs cell junction formation during embryonic myogenesisSemantic proximity Read

A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal MusclesSemantic proximity Read

Myogenic Differentiation of Muscular Dystrophy-Specific Induced Pluripotent Stem Cells for Use in Drug DiscoverySemantic proximity Read

Skeletal muscle cells derived from induced pluripotent stem cells: A platform for limb girdle muscular dystrophiesSemantic proximity Read

Skeletal Muscle Cells Derived from Induced Pluripotent Stem Cells: A Platform for Limb Girdle Muscular DystrophiesSemantic proximity Read

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modelingSemantic proximity Read

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model.Semantic proximity Read

Pluripotent Stem Cells in Disease Modeling and Drug Discovery for Myotonic Dystrophy Type 1Semantic proximity Read