Article

Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth <i>in vivo</i>

2023-04-08

Abstract excerpt

Small bowel neuroendocrine tumors (SBNETs) originate from enterochromaffin cells in the intestine which synthesize and secrete serotonin. SBNETs express high levels of tryptophan hydroxylase 1 (Tph1), a key enzyme in serotonin biosynthesis. Patients with high serotonin level may develop carcinoid syndrome, which can be treated with somatostatin analogues and the Tph1 inhibitor telotristat ethyl in severe cases. Al...

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Literature Corpus work: 4b122757-db77-5454-80c2-1951581ace15
DOI: 10.1101/2023.04.07.536013

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