Article
Effects and related mechanisms of serotonin on malignant biological behavior of hepatocellular carcinoma via regulation of Yap.
Oncotarget - 18 Jul 2017
Liu Sushun, Miao Runchen, Zhai Mimi, Pang Qing, Deng Yan, Liu Sinan, Qu Kai, Liu Chang, Zhang Jingyao
Abstract excerpt
5-hydroxytryptamine (5-HT, serotonin) and Yes-associated protein (Yap), which act as a mitogen and an oncogene, respectively, play an important role in tumors. Here, we investigated whether 5-HT could affect the hepatocarcinogenic process via promoting the activation and expression of Yap, as well as the possible underlying molecular mechanisms. We found that 5-HT promoted hepatoma cell proliferation, invasion...
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