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Serotonin Expression and β-Cell Phenotype Are Associated With Indolent Behavior in Pancreatic Neuroendocrine Tumors With Sclerosing Morphology.

Journal of surgical oncology - 1 Jun 2026

Windon Annika L, Revetta Frank, Chen Wei, Shi Chanjuan

Abstract excerpt

BACKGROUND AND OBJECTIVES: ARX and PDX1 transcription factors have been considered indicators of the cell of origin for pancreatic neuroendocrine tumors (PanNETs). Some PanNETs show dense fibrosis (sclerosing morphology) and an association with serotonin expression. This study aimed to explore ARX and PDX1 expression in these tumors. METHODS: Pathology archives were searched from 2005 to 2019 for PanNETs with...

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Biomarkers, Tumor
Homeodomain Proteins
Liver Neoplasms
Neuroendocrine Tumors
Pancreatic Neoplasms

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Identifiers

PMID: 41936041
DOI: 10.1002/jso.70247
PMCID: PMC13352224

Genes

ARX
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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