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Article

Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model.

Endocrinology - 1 Jan 2011

Wu S Vincent, Yuan Pu-Qing, Lai Jim, Wong Kelvin, Chen Monica C, Ohning Gordon V, Taché Yvette

Abstract excerpt

CRH and 5-hydroxytryptamine (5-HT) are expressed in human colonic enterochromaffin (EC) cells, but their interactions at the cellular level remain largely unknown. The mechanistic and functional relationship between CRH and 5-HT systems in EC cells was investigated in a human carcinoid cloned BON cell line (BON-1N), widely used as an in vitro model of EC cell function. First, we identified multiple CRH(1) splice...

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Share to Cell Line, Tumor
Share to CRF Receptor, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

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Share to Receptors, Corticotropin-Releasing Hormone

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Share to Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 21123435
DOI: 10.1210/en.2010-0997
PMCID: PMC3219048

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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