Article

Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

2021-10-01

Abstract excerpt

<h4>Summary</h4> Chi3l1 (Chitinase 3-like 1) is a secreted protein highly expressed in glioblastoma. Here, we show that exposure of glioma stem cells (GSCs) to Chi3l1 reduces the CD133 + /SOX2 + cells and increases the CD44 + /Chi3l1 + cells. Chi3l1 binds to CD44 and induces phosphorylation and nuclear translocation of beta-catenin, Akt and STAT3. Single cell RNA-seq and RNA velocity following incubation of G...

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Literature Corpus work: 4b01d17c-7730-51ce-8c28-e3069cc507ea
DOI: 10.1101/2021.10.01.462786

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