Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells.

Life science alliance - 1 Jun 2019

Gao Yankun, Dutta Banik Debarghya, Muna Mutia M, Roberts Stefan Ge, Medler Kathryn F

Abstract excerpt

WT1 is a transcriptional activator that controls the boundary between multipotency and differentiation. The transcriptional cofactor BASP1 binds to WT1, forming a transcriptional repressor complex that drives differentiation in cultured cells; however, this proposed mechanism has not been demonstrated in vivo. We used the peripheral taste system as a model to determine how BASP1 regulates the function of WT1....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calmodulin-Binding Proteins
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Gene Knockdown Techniques

Share to Mice, Transgenic

Share to Nerve Tissue Proteins

Share to Taste Buds

Share to WT1 Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 31167803
DOI: 10.26508/lsa.201800287
PMCID: PMC6555901

Genes

WT1
BASP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells.PMID 31167803Read ↗

WT1 regulates the development of the posterior taste field.Semantic proximity Read ↗

The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells.Semantic proximity Read ↗

Generation of Human Taste Bud Organoids as a Human-Mimetic Platform for Modeling Taste PerceptionSemantic proximity Read ↗

Foxi1 regulates multipotent mucociliary progenitors and ionocyte specification through transcriptional and epigenetic mechanismsSemantic proximity Read ↗

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.Semantic proximity Read ↗

PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cellsSemantic proximity Read ↗

Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue.Semantic proximity Read ↗

WT1 in disease: shifting the epithelial-mesenchymal balance.Semantic proximity Read ↗

Sox2 is required for development of taste bud sensory cells.Semantic proximity Read ↗

Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.Semantic proximity Read ↗

A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice.Semantic proximity Read ↗

TRPM5 <sup>+</sup> microvillous tuft cells regulate neuroepithelial intrinsic olfactory stem cell proliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.