Article

Spermatogenic context controls outcomes of engineered sex distortion in malaria mosquitoes

2026-03-31

Abstract excerpt

Sex-ratio distortion systems are promising genetic tools for mosquito population control. Two strategies have been proposed: prezygotic elimination of X-bearing sperm by X-shredding, which can drive invasive Y-chromosome transmission when sex distorters are Y-linked, and postzygotic daughter killing through disruption of X-linked haploinsufficient genes, a self-limiting approach known as X-poisoning. Previous atte...

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Literature Corpus work: 4add4af9-81cf-53ec-8c3d-04569e658081
DOI: 10.64898/2026.03.29.715086

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