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Article

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae

11 May 2020

Abstract excerpt

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce unisex populations that eventually collapse, but the underlying molecular mechanisms are unknown. We report a male-biased sex-distorter gene drive (SDGD) in the human...

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PMID: 32393821
DOI: 10.1038/s41587-020-0508-1

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