Article

Essential function of <i>femaleless</i> in female gametogenesis controls gene drive spread in <i>Anopheles gambiae</i>

2026-08-24

Abstract excerpt

Insecticide resistance in mosquito vectors and antimalarial drug resistance in parasites threaten progress towards malaria elimination, prompting the development of alternative control strategies such as CRISPR-Cas9 gene drives. The sex determination gene femaleless (fle, AGAP013051), which is required for female development in Anopheles gambiae, is a promising target for population-suppression approaches aimed at...

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Literature Corpus work: 08edd09b-33a0-59d6-a564-9c34084399bc
DOI: 10.64898/2026.08.22.746406

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