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Rich2 inhibits the NLRP3 inflammasome in epilepsy formation by regulating autophagy

2023-09-11

Abstract excerpt

<h4>Background: </h4> The intricate pathophysiology of epilepsy has hindered the advancement of efficacious therapies. Despite the existence of a dozen antiseizure drugs (ASDs) with favorable effects on seizure management globally, approximately 30% of patients continue to exhibit resistance to ASDs. Neuroinflammation seems to play a pivotal role in the disease's progression. Rich2 (Rho GTP enzyme-activated protei...

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Literature Corpus work
4ad448a9-9139-5c48-abbd-c6ca2614f15e
DOI
10.21203/rs.3.rs-3322926/v1
Open publication

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