Article
HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis.
European journal of immunology - 1 Jan 2012
Matthews Kerryn, Ntsekhe Mpiko, Syed Faisal, Scriba Thomas, Russell James, Tibazarwa Kemi, Deffur Armin, Hanekom Willem, Mayosi Bongani M, Wilkinson Robert J, Wilkinson Katalin A
Abstract excerpt
HIV-1-infected people have an increased risk of developing extrapulmonary tuberculosis (TB), the immunopathogenesis of which is poorly understood. Here, we conducted a detailed immunological analysis of human pericardial TB, to determine the effect of HIV-1 co-infection on the phenotype of Mycobacterium tuberculosis (MTB)-specific memory T cells and the role of polyfunctional T cells at the disease site, using...
Topics
- Adult
- Aged
- Aged, 80 and over
- CD4-Positive T-Lymphocytes
- Female
- Flow Cytometry
- HIV Infections
- HIV-1
- Humans
- Immunologic Memory
- Interferon-gamma