Article

Organelle phenotyping and multi-dimensional microscopy identify C1q as a novel regulator of microglial function

2023-12-12

Abstract excerpt

Microglia, the immune cells of the central nervous system (CNS), are incredibly dynamic and heterogenous cells. While single cell RNA sequencing has become the conventional methodology for evaluating microglial state, transcriptomics do not provide insight into functional changes. Here, we propose a novel organelle phenotyping approach where we treat live human induced pluripotent stem cell-derived microglia (iMGL...

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Literature Corpus work: 4abe2106-c4aa-5a56-9d42-f20f21fcbee9
DOI: 10.1101/2023.12.12.571151

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