Article

Single-cell mass spectrometry imaging combined with immunofluorescence reveals neutrophil heterogeneity in inflammation

2025-08-22

Abstract excerpt

Multimodal single-cell approaches allow for a holistic analysis of complex biological systems. In this study, we developed a novel single-cell analysis pipeline integrating immunofluorescence-based protein with mass spectrometry imaging-based lipid analysis of circulating human neutrophils. The combination of both modalities identified the emergence of pathogenic neutrophils in liver cirrhosis patients thus epitom...

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Literature Corpus work: 6ec2a1bf-162a-551d-86c8-3101ef1fdb57
DOI: 10.1101/2025.08.19.671021

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