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Copper-Free Click Chemistry Enables High-Fidelity Engineering of Mitochondria-Targeted Brain-Derived Exosomes

2025-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction is a hallmark of neurodegenerative and neuroinflammatory disorders, including hypertension and cardiovascular disease, yet strategies for safe and precise mitochondrial-targeted delivery remain limited. Here, we establish strain-promoted azide–alkyne cycloaddition (SPAAC) as a biocompatible, high-fidelity chemical platform for engineering mitochondria-targeted brain-der...

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Literature Corpus work: 4ab9b47b-24b8-5823-98f5-126f3947d463
DOI: 10.1101/2025.11.19.689327

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Copper-Free Click Chemistry Enables High-Fidelity Engineering of Mitochondria-Targeted Brain-Derived ExosomesDOI 10.1101/2025.11.19.689327Read

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