Article

Rescuable sleep and synaptogenesis phenotypes in a <i>Drosophila</i> model of O-GlcNAc transferase intellectual disability

2023-06-30

Abstract excerpt

O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recently, missense mutations in OGT have been linked to intellectual disability, indicating that this modification is important for the development and functioning of the nervous system. However, the processes that are most sensitive to perturbations in O-GlcNAcylation remain to be iden...

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Literature Corpus work: 7687ffcb-ef47-5e67-83fb-b1f186fa3285
DOI: 10.1101/2023.06.28.546900

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