Article

NADH-DLEM-seq: A High-Fidelity Multimodal Platform Revealing Fiber-Type-Specific Metabolic and Transcriptional Remodeling in Sarcopenia

2026-03-26

Abstract excerpt

<title>Abstract</title> <p>Unraveling the spatial heterogeneity of tissue microenvironments is essential for understanding complex pathologies like sarcopenia. However, existing spatial omics technologies often compromise between single-cell resolution, macromolecular integrity, and metabolic context. Here, we present "Donut" Laser Ejection Microdissection (DLEM), a high-throughput, non-contact spatial sampling p...

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Literature Corpus work: 4aade198-14b3-50dd-80d0-e43e84d8119e
DOI: 10.21203/rs.3.rs-9027627/v1

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