Article

Splicing buffers suboptimal codon usage in human cells

2019-01-22

Abstract excerpt

Although multiple studies have addressed the effects of codon usage on gene expression, such studies were typically performed in unspliced model genes. In the human genome, most genes undergo splicing and patterns of codon usage are splicing-dependent: guanine and cytosine (GC) content is highest within single-exon genes and within first exons of multi-exon genes. Intrigued by this observation, we measured the eff...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a8e4fd4-ff35-5e09-afea-d34772dce284
DOI: 10.1101/527440

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Splicing buffers suboptimal codon usage in human cellsDOI 10.1101/527440Read

Splice-Aware Optimization Prevents Pervasive Missplicing of Natural and Synthetic cDNAsSemantic proximity Read

Pervasive noise in human splice site selectionSemantic proximity Read

Context-dependent robustness to 5' splice site polymorphisms in human populations.Semantic proximity Read

Noisy splicing drives mRNA isoform diversity in human cells.Semantic proximity Read

Differential GC content between exons and introns establishes distinct strategies of splice-site recognition.Semantic proximity Read

Global impact of aberrant splicing on human gene expression levelsSemantic proximity Read

Nucleotide frequency variation across human genes.Semantic proximity Read

5' splice site GC>GT and GT>GC variants differ markedly in terms of their functionality and pathogenicity.Semantic proximity Read

5’ splice site GC>GT variants differ from GT>GC variants in terms of their functionality and pathogenicitySemantic proximity Read

First estimation of the scale of canonical 5’ splice site GT>GC mutations generating wild-type transcripts and their medical genetic implicationsSemantic proximity Read

Interpreting mammalian evolutionary constraint at synonymous sites in light of the unwanted transcript hypothesisSemantic proximity Read

Synonymous codon usage regulates translation initiationSemantic proximity Read