Back to search

Article

Survival of the “unfittest”: clinical emergence of hyper-multidrug-resistant <i>Nakaseomyces glabratus</i> with rare nonfunctional Erg3 and Erg11 and severely impaired fitness

2025-02-05

Abstract excerpt

<h4>Background</h4> Nakaseomyces glabratus ( Candida gabrata ) poses a significant clinical challenge due to common drug resistance. We report a case of a complicated urinary tract infection (UTI) progressing to prostatitis and urosepsis, with the emergence of a hyper-multidrug-resistant isolate with low stress tolerance, slow growth and a short life span. This study elucidates the genetic mechanisms and phenoty...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0da677e7-332a-5d98-bcd7-390472b37b09
DOI
10.1101/2025.02.05.636719
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Survival of the “unfittest”: clinical emergence of hyper-multidrug-resistant <i>Nakaseomyces glabratus</i> with rare nonfunctional Erg3 and Erg11 and severely impaired fitnessDOI 10.1101/2025.02.05.636719
Ergosterol-depleted clinical isolates of <i>Nakaseomyces glabratus</i> can develop multi-drug resistance without apparent fitness and virulence defectsSemantic proximity
Micafungin exposure drives multidrug resistance in <i>Clavispora lusitaniae</i>Semantic proximity
Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the <i>Mucor</i> species complexSemantic proximity
Antifungal resistance mechanisms and nosocomial transmission of <i>Nakaseomyces glabratus</i> : genomic investigation and observational study in Melbourne, AustraliaSemantic proximity
Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i>Semantic proximity
Aminoglycoside heteroresistance in <i>Enterobacter cloacae</i> is driven by the cell envelope stress responseSemantic proximity
Redefining Pleiotropic Drug Resistance in a Pathogenic Yeast: Pdr1 Functions as a Sensor of Cellular Stresses in <i>Candida glabrata</i>Semantic proximity
What makes <i>Candida auris</i> pan-drug resistant? Integrative insights from genomic, transcriptomic, and phenomic analysis of clinical strains resistant to all four major classes of antifungal drugsSemantic proximity
A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen <i>Candida glabrata</i>Semantic proximity
Acquired amphotericin B resistance attributed to a mutated ERG3 in Candidozyma auris.Semantic proximity
Fungal pathogens exposed – genomic and phenotypic insights into <i>Candida auris</i> and its relatives of the <i>Candida haemulonii</i> species complexSemantic proximity
Identification of essential genes and fluconazole resistance genes in <i>Candida glabrata</i> by profiling of <i>Hermes</i> transposon insertionsSemantic proximity
Select a neighboring publication to make it the new centre.