Article

Spontaneous aggressive ERα+ mammary tumor model is driven by Kras activation

2018-10-16

Abstract excerpt

<h4>Summary</h4> The NRL-PRL murine model, defined by mammary-selective transgenic rat prolactin ligand rPrl expression, establishes spontaneous ER+ mammary tumors, mimicking the association between elevated prolactin (PRL) and risk for development of ER+ breast cancer in postmenopausal women. Whole genome and exome sequencing in a discovery cohort (n=5) of end stage tumors revealed canonical activating mutation...

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Literature Corpus work: 4a339758-d35b-5e6b-baed-a9c7832b135f
DOI: 10.1101/442624

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