Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation

1 Aug 2019

Abstract excerpt

The NRL-PRL murine model, defined by mammary-selective transgenic rat prolactin ligand rPrl expression, establishes spontaneous ER+ mammary tumors in nulliparous females, mimicking the association between elevated prolactin (PRL) and risk for development of ER+ breast cancer in postmenopausal women. Whole-genome and exome sequencing in a discovery cohort (n = 5) of end-stage tumors revealed canonical activating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Lung Cancer Research Studies
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31390566
DOI: 10.1016/j.celrep.2019.06.098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras ActivationPMID 31390566Read ↗

Spontaneous aggressive ERα+ mammary tumor model is driven by Kras activationSemantic proximity Read ↗

Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas.Semantic proximity Read ↗

Single-cell RNA sequencing identifies the prolactin receptor as a therapeutic target in adenomyosisSemantic proximity Read ↗

Breast Cancer and Prolactin – New Mechanisms and ModelsSemantic proximity Read ↗

The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.Semantic proximity Read ↗

Prolactin Pro-Differentiation Pathway in Triple Negative Breast Cancer: Impact on Prognosis and Potential TherapySemantic proximity Read ↗

Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivo.Semantic proximity Read ↗

Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer PatientsSemantic proximity Read ↗

Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analysesSemantic proximity Read ↗

Longitudinal single cell RNA-sequencing of <i>Pik3ca</i> <sup>H1047R</sup> -driven mammary tumorigenesis reveals coordinated transformation of epithelial and fibroblast transcriptional statesSemantic proximity Read ↗

Obesity modifies cell fate plasticity of <i>Pdgfrα-</i> expressing adipocyte progenitors to promote an aberrant mammary microenvironmentSemantic proximity Read ↗

Obesity modifies cell fate plasticity of Pdgfrα-expressing adipocyte progenitors to promote an aberrant mammary microenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.