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DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases

14 Jul 2025

Abstract excerpt

BACKGROUND: The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized. METHODS: We calculated the American Heart Association’s Life’s Essential 8 score to reflect CVH in 5 cohorts with diverse backgrounds (mean age 54 years, 55% women, and enrollment year ranging from 1989 to 2012). Epigenome-wide association studies (EWAS) for Life’s Essential 8...

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PMID: 40654086
DOI: 10.1161/circulationaha.124.073181

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