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An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis

14 Jan 2020

Abstract excerpt

Abstract The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with “idiopathic” gamma‐aminobutyric‐acid‐A receptor (GABAA‐R) encephalitis by next‐generation sequencing and single‐cell analyses. We identified a CD8+ T cell clone that was strongly expanded...

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PMID: 31943946
DOI: 10.1002/acn3.50974

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