Article

A Novel Low-Risk Germline Variant in the SH2 Domain of the SRC Gene Affects Multiple Pathways in Familial Colorectal Cancer

2021-03-03

Abstract excerpt

Colorectal cancer (CRC) shows one of the largest proportions of familial cases among different malignancies, but only 5-10% of all CRC cases are linked to mutations in established predisposition genes. Thus, familial CRC constitutes a promising target for the identification of novel, high- to moderate-penetrance germline variants underlying cancer susceptibility by next generation sequencing. In this study, we per...

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Literature Corpus work: 4a1b4e96-88dd-5e1c-9c41-9dbbd68fb40f
DOI: 10.20944/preprints202103.0121.v1

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