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Article

Somatic mutations and germline sequence variants in patients with familial colorectal cancer.

International journal of cancer - 15 Dec 2010

Gylfe Alexandra E, Sirkiä Johanna, Ahlsten Manuel, Järvinen Heikki, Mecklin Jukka-Pekka, Karhu Auli, Aaltonen Lauri A

Abstract excerpt

It is estimated that up to 35% of colorectal cancers (CRC) can be explained by hereditary factors. However, genes predisposing to highly penetrant CRC syndromes account for only a small fraction of all cases. Thus, most CRCs still remain molecularly unexplained. A recent systematic sequencing study on well-annotated human protein coding genes identified 280 somatically mutated candidate cancer genes (CAN genes)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Identifiers

PMID: 21351276
DOI: 10.1002/ijc.25529

Genes

CSMD3
EPHB6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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