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Article

Hepatocyte nuclear factor 1β controls nephron tubular development

29 Jan 2013

Abstract excerpt

Nephron morphogenesis is a complex process that generates blood-filtration units (glomeruli) connected to extremely long and patterned tubular structures. Hepatocyte nuclear factor 1β (HNF1β) is a divergent homeobox transcription factor that is expressed in kidney from the first steps of nephrogenesis. Mutations in HNF1B (OMIM #137920) are frequently found in patients with developmental renal pathologies, the...

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PMID: 23362349
DOI: 10.1242/dev.086546

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