Article

Quantifying memory CD8 T cell-mediated immune pressure on influenza A virus infection <i>in vivo</i>

2020-01-27

Abstract excerpt

The conservation of T cell epitopes in human influenza A virus has prompted the development of T cell-inducing influenza vaccines. However, the selection pressure mediated by memory CD8 T cells upon influenza virus has not been directly measured. Using a droplet digital PCR technique to distinguish wild-type and an epitope-mutant PR8 influenza viruses in vivo , this study quantifies the viral replicative fitness...

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Literature Corpus work: 49f565ca-c20f-586a-b897-43371fe202de
DOI: 10.1101/2020.01.27.921031

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