Article

Kif2C safeguards radial glial integrity to prevent cortical malformation

2026-05-24

Abstract excerpt

Radial glial cells (RGCs) generate cortical neurons and guide radial neuronal migration, yet how microtubule (MT) regulators coordinate progenitor maintenance, mitotic fidelity, and cortical architecture remains unclear. Here, we identify the MT depolymerase Kif2C/MCAK as an essential regulator of RGC integrity with relevance to human neurodevelopmental disorders. Kif2C is enriched in developing cortical RGCs and...

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Literature Corpus work: 49d28eae-7612-5071-a91e-1c39ea435c5a
DOI: 10.64898/2026.05.22.726143

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