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Article

Complete blood count differences in a cohort of Down syndrome neonates with transient abnormal myelopoiesis screened for GATA1 pathogenic variants.

American journal of medical genetics. Part A - 1 Sept 2020

Orozco-Vela Mireya, Corona-Rivera Alfredo, Cruz-Osorio Rosa Margarita, Mendoza-Maldonado Lucero, Márquez-Mora Aurea, Barba-Barba César Cenobio, Peña-Padilla Christian, Baldomero-López Alejandra, Bobadilla-Morales Lucina, Corona-Rivera Jorge Román

Abstract excerpt

Transient abnormal myelopoiesis (TAM) raises the risk for acute myeloid leukemia of Down syndrome (DS) (ML-DS), and both are related to GATA1 pathogenic variants. Here, we analyzed which findings on complete blood count (CBC) are associated with TAM in a cohort of neonates with DS screened for GATA1 pathogenic variants. The CBCs were compared among 70 newborns with DS, including 16 patients (22.9%) with TAM...

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Acute Myeloid Leukemia Research
Blood Cell Count
Blood disorders and treatments
Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

GATA1 Transcription Factor

Infant, Newborn

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PMID: 32681702
DOI: 10.1002/ajmg.a.61748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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