Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder.

Singapore medical journal - 1 Jun 2016

Lum Su Han, Choong Soo Sin, Krishnan Shekhar, Mohamed Zulqarnain, Ariffin Hany

Abstract excerpt

INTRODUCTION: Children with Down syndrome (DS) are at increased risk of developing distinctive clonal myeloid disorders, including transient abnormal myelopoiesis (TAM) and myeloid leukaemia of DS (ML-DS). TAM connotes a spontaneously resolving congenital myeloproliferative state observed in 10%-20% of DS newborns. Following varying intervals of apparent remission, a proportion of children with TAM progress to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down Syndrome
Share to GATA1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Genomics

Share to Leukemia, Myeloid

Share to Malaysia

Share to Referral and Consultation

Share to Remission Induction

Source

Open in PubMed Open full text

Identifiers

PMID: 27353457
DOI: 10.11622/smedj.2016106
PMCID: PMC4971451

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder.PMID 27353457Read ↗

Sensitive GATA1 mutation screening reliably identifies neonates with Down syndrome at risk for myeloid leukemiaSemantic proximity Read ↗

Analysis of GATA1 mutations and leukemogenesis in newborns with Down syndrome.Semantic proximity Read ↗

Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndromeSemantic proximity Read ↗

Transient Abnormal Myelopoiesis and AML in Down Syndrome: an UpdateSemantic proximity Read ↗

The natural history of transient abnormal myelopoiesis in neonates and children with Down syndromeSemantic proximity Read ↗

Distinctive hematological abnormalities in East Asian neonates and children with Down syndrome.Semantic proximity Read ↗

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome.Semantic proximity Read ↗

Natural history of GATA1 mutations in Down syndrome.Semantic proximity Read ↗

Hematological disorders in children with Down syndrome.Semantic proximity Read ↗

GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.Semantic proximity Read ↗

Clinical and biological aspects of myeloid leukemia in Down syndrome.Semantic proximity Read ↗

Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.