Article

Mutational signatures of replication timing and epigenetic modification persist through the global divergence of mutation spectra across the great ape phylogeny

2019-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Great ape clades exhibit variation in the relative mutation rates of different three-base-pair genomic motifs, with closely related species having more similar mutation spectra than distantly related species. This pattern cannot be explained by classical demographic or selective forces, but imply that DNA replication fidelity has been perturbed in different ways on each branch of the great ape p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 49a0d860-11d0-5e76-9ecc-13f3078b9ae7
DOI: 10.1101/805598

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutational signatures of replication timing and epigenetic modification persist through the global divergence of mutation spectra across the great ape phylogenyDOI 10.1101/805598Read

Mutational Signatures of Replication Timing and Epigenetic Modification Persist through the Global Divergence of Mutation Spectra across the Great Ape Phylogeny.Semantic proximity Read

A Phylogeny-Based Approach to Discover Mutational Processes in PrimatesSemantic proximity Read

Population dynamics of GC-changing mutations in humans and great apesSemantic proximity Read

The mutation spectrum in genomic late replication domains shapes mammalian GC content.Semantic proximity Read

Germline hypomethylation shapes dynamic CpG reservoirs in ape genomesSemantic proximity Read

Evolution of Replication Origins in Vertebrate Genomes: Rapid Turnover Despite Selective ConstraintsSemantic proximity Read

Mutation rates in mammalian genomes.Semantic proximity Read

Evolutionary Dynamics of G-Quadruplexes in Human and Other Great Ape Telomere-to-Telomere GenomesSemantic proximity Read

Evolution of the Mutation Spectrum Across a Mammalian Phylogeny.Semantic proximity Read

Differential relationship of DNA replication timing to different forms of human mutation and variation.Semantic proximity Read

Evolution of local mutation rate and its determinantsSemantic proximity Read

The diversity of class II transposable elements in mammalian genomes has arisen from ancestral phylogenetic splits during ancient waves of proliferation through the genome.Semantic proximity Read