Article

Cholangiocytes’ Primary Cilia Regulate DNA Damage Response and Repair

2025-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Primary cilia have been considered tumor-suppressing organelles in cholangiocarcinoma (CCA), though the mechanisms behind their protective role are not fully understood. This study investigates how the loss of primary cilia affects DNA damage response (DDR) and DNA repair processes in CCA. Human cholangiocyte cell lines were used to examine the colocalization of DNA repair proteins at the cilia...

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Literature Corpus work: 0432f45f-27b4-5177-a4d7-7a768778e767
DOI: 10.1101/2025.01.28.635267

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