Article

Therapy-induced normal tissue damage promotes breast cancer metastasis

2020-10-17

Abstract excerpt

Disseminated tumour cells frequently exhibit a period of dormancy that renders them insensitive to targeting by chemotherapeutic agents, conversely the systemic delivery of chemotherapies can result in normal tissue damage. Using multiple mouse and human breast cancer models, we demonstrate that prior chemotherapy administration enhances metastatic colonisation and outgrowth. In vitro , chemotherapy treatment ind...

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Literature Corpus work: 4966609b-0392-5923-a176-8fb6ca90985b
DOI: 10.1101/2020.10.17.343590

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