Article
A toxin-antitoxin module as a target for antimicrobial development.
Plasmid - 1 Jan 2010
Lioy Virginia S, Rey Oscar, Balsa Dolors, Pellicer Teresa, Alonso Juan C
Abstract excerpt
The emergence and spread of pathogenic bacteria that have become resistant to multiple antibiotics through lateral gene transfer have created the need of novel antimicrobials. Toxin-antitoxin (TA) modules, which have been implicated in plasmid maintenance and stress management, are ubiquitous among plasmids from vancomycin or methicillin resistant bacteria. In the Streptococcus pyogenes pSM19035-encoded TA loci,...
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